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| Sunday, October 9th , 1910 |
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| 3B Red Smith retired from professional baseball. |
| Purchased the contract of C Bill DeLancey from Double A Ewa Gentry. |
| Monday, September 19th , 1910 |
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| Placed CF George Gore on the active roster. |
| Activated CF George Gore from the injured list. |
| Friday, August 12th , 1910 |
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| Signed 1B Joe Adcock to a 3-year contract extension worth a total of $3,600. |
| Monday, August 1st , 1910 |
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| Placed CF George Gore on the 14-day injured list, retroactive to 07/29/1910. |
| Purchased the contract of CF Bobby Del Greco from Triple A Iowa. |
| Monday, May 30th , 1910 |
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| Optioned CF Bobby Del Greco to Triple A Iowa. |
| Placed RF James Roseman on the active roster. |
| Activated RF James Roseman from the injured list. |
| Monday, April 25th , 1910 |
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| Assigned LF Chuck Essegian to Triple A Iowa. |
| Monday, April 4th , 1910 |
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| Optioned RP Ken Holloway to Triple A Iowa. |
| Optioned RP Mike Munoz to Triple A Iowa. |
| Optioned C Junior Ortiz to Triple A Iowa. |
| Optioned 1B Mike Lum to Triple A Iowa. |
| Optioned 3B Jim Davenport to Triple A Iowa. |
| Optioned SS Adam Everett to Triple A Iowa. |
| Optioned SS Sibby Sisti to Triple A Iowa. |
| Optioned SS Ryan Theriot to Triple A Iowa. |
| LF Chuck Essegian was designated for assignment and placed on waivers. |
| Placed RF James Roseman on the 14-day injured list, retroactive to 04/01/1910. |
| Optioned RF Eduardo Perez to Triple A Iowa. |
| Optioned CF Al Nixon to Triple A Iowa. |
| Optioned 2B Esteban German to Triple A Iowa. |
| Purchased the contract of 2B Esteban German from Triple A Iowa. |
| Monday, February 28th , 1910 |
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| Purchased the contract of C Junior Ortiz from Triple A Iowa. |
| Purchased the contract of SS Adam Everett from Triple A Iowa. |
| Purchased the contract of SS Sibby Sisti from Triple A Iowa. |
| Purchased the contract of RP Ken Holloway from Triple A Iowa. |
| Purchased the contract of 1B Mike Lum from Triple A Iowa. |
| Purchased the contract of RP Xavier Cedeno from Triple A Iowa. |
| Purchased the contract of RF Eduardo Perez from Triple A Iowa. |
| Purchased the contract of RP Mike Munoz from Triple A Iowa. |
| Monday, January 3rd , 1910 |
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| Placed 1B Joe Adcock on the active roster. |
